表皮生長因子受體
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表皮生長因子受體（英語：epidermal growth factor receptor，簡稱為EGFR、ErbB-1或HER1）是一類名為表皮生長因子家族（EGF-家族）的細胞外蛋白配體的細胞表面受體[2] 。
表皮生長因子受體是ErbB受體家族家族的成員之一，ErbB家族是包含四種緊密聯(lián)系蛋白的亞家族，這四種蛋白分別是受體酪氨酸激酶類：EGFR（ErbB-1）HER2/c-neu（ErbB-2）、Her 3（ErbB-3）以及Her 4（ErbB-4）。影響EGFR表達或活性的突變可能導(dǎo)致癌癥[3]。
表皮生長因子及其受體是由范德堡大學(xué)的斯坦利·科恩發(fā)現(xiàn)的，科恩與麗塔·列維-蒙塔爾奇尼因發(fā)現(xiàn)生長因子類而共同獲得了1986年諾貝爾生理學(xué)或醫(yī)學(xué)獎。
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功能
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表皮生長因子受體（EGFR）存在于細胞表面且因結(jié)合特異性受體而被激活，這些受體包括表皮生長因子和TGFα。ErbB2并無已知的直接激活配體，可能結(jié)構(gòu)性地處于激活狀態(tài)，或在與如EGFR等其他家族成員形成異源二聚體時被激活。
參考文獻
- ↑ PMID 12620237（PubMed）
本引用來源將會在數(shù)十分鐘后自動完成。您可以檢查英文對應(yīng)模板或手動擴充 - ↑ Herbst RS. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys.. 2004, 59 (2 Suppl): 21–6. doi:10.1016/j.ijrobp.2003.11.041. PMID 15142631.
- ↑ Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1934579/ ErbB receptors: from oncogenes to targeted cancer therapies]. J. Clin. Invest.. August 2007, 117 (8): 2051–8. doi:10.1172/JCI32278. PMID 17671639. PMC 1934579.
深入閱讀
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