腺苷脫氨酶

Adenosine deaminase (editase) domain
鑒定
標(biāo)志	A_deamin
Pfam（蛋白家族查詢(xún)站）	PF02137
InterPro（蛋白數(shù)據(jù)整合站）	IPR002466
PROSITE（蛋白數(shù)據(jù)站）	PDOC00419
SCOP（蛋白結(jié)構(gòu)分類(lèi)數(shù)據(jù)站）	1add
現(xiàn)有可用的蛋白結(jié)構(gòu)：
Pfam	structures
PDB（蛋白質(zhì)數(shù)據(jù)庫(kù)）	RCSB PDB; PDBe
PDBsum（蛋白質(zhì)三維結(jié)構(gòu)站）	structure summary

Adenosine/AMP deaminase
	crystal structure of plasmodium yoelii adenosine deaminase (py02076)
鑒定
標(biāo)志	A_deaminase
Pfam（蛋白家族查詢(xún)站）	PF00962
Pfam宗系	CL0034
InterPro（蛋白數(shù)據(jù)整合站）	IPR001365
PROSITE（蛋白數(shù)據(jù)站）	PDOC00419
SCOP（蛋白結(jié)構(gòu)分類(lèi)數(shù)據(jù)站）	1add
現(xiàn)有可用的蛋白結(jié)構(gòu)：
Pfam	structures
PDB（蛋白質(zhì)數(shù)據(jù)庫(kù)）	RCSB PDB; PDBe
PDBsum（蛋白質(zhì)三維結(jié)構(gòu)站）	structure summary

腺苷脫氨酶
	; 牛腺苷脫氨酶的絲帶圖。可見(jiàn)中央的鋅離子。來(lái)自PDB 1VFL
有效結(jié)構(gòu)
PDB	直系同源檢索：PDBe, RCSB
PDB查詢(xún)代碼列表
	1M7M, 3IAR
標(biāo)識(shí)
代號(hào)	ADA;
擴(kuò)展標(biāo)識(shí)	遺傳學(xué)：608958 鼠基因：87916 同源基因：37249 GeneCards: ADA Gene
EC編號(hào)	3.5.4.4
基因本體論描述
分子功能	· purine nucleoside binding; · adenosine deaminase activity; · adenosine deaminase activity; · adenosine deaminase activity; · protein binding; · zinc ion binding; · zinc ion binding; · hydrolase activity; · metal ion binding;
細(xì)胞成分	· extracellular space; · cytoplasm; · lysosome; · cytosol; · plasma membrane; · external side of plasma membrane; · cell surface; · membrane; · cell junction; · cytoplasmic vesicle; · dendrite cytoplasm; · neuronal cell body; · cytoplasmic membrane-bounded vesicle lumen;
生物過(guò)程	· response to hypoxia; · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · · in utero embryonic development; class="plainlinks">trophectodermal cell differentiation; class="plainlinks">liver development; class="plainlinks">placenta development; class="plainlinks">germinal center B cell differentiation; class="plainlinks">positive regulation of germinal center formation; class="plainlinks">negative regulation of leukocyte migration; class="plainlinks">negative regulation of mature B cell apoptosis; class="plainlinks">purine base metabolic process; class="plainlinks">adenosine catabolic process; class="plainlinks">adenosine catabolic process; class="plainlinks">deoxyadenosine catabolic process; class="plainlinks">cell adhesion; class="plainlinks">aging; class="plainlinks">nucleotide metabolic process; class="plainlinks">purine ribonucleoside monophosphate biosynthetic process; class="plainlinks">positive regulation of heart rate; class="plainlinks">positive regulation of B cell proliferation; class="plainlinks">purine nucleotide salvage; class="plainlinks">positive regulation of T cell differentiation in thymus; class="plainlinks">regulation of cell-cell adhesion mediated by integrin; class="plainlinks">T cell activation; class="plainlinks">response to hydrogen peroxide; class="plainlinks">negative regulation of apoptosis; class="plainlinks">purine-containing compound salvage; class="plainlinks">regulation of circadian sleep/wake cycle, sleep; class="plainlinks">positive regulation of smooth muscle contraction; class="plainlinks">dATP catabolic process; class="plainlinks">hypoxanthine biosynthetic process; class="plainlinks">inosine biosynthetic process; class="plainlinks">inosine biosynthetic process; class="plainlinks">xanthine biosynthetic process; class="plainlinks">positive regulation of alpha-beta T cell differentiation; class="plainlinks">lung alveolus development; class="plainlinks">Peyer's patch development; class="plainlinks">embryonic digestive tract development; class="plainlinks">negative regulation of inflammatory response; class="plainlinks">positive regulation of calcium-mediated signaling; class="plainlinks">positive regulation of T cell receptor signaling pathway; class="plainlinks">nucleobase, nucleoside and nucleotide metabolic process; class="plainlinks">negative regulation of adenosine receptor signaling pathway; class="plainlinks">negative regulation of penile erection; class="plainlinks">negative regulation of thymocyte apoptosis; · negative regulation of mucus secretion;
	Sources: Amigo / QuickGO
RNA表達(dá)模式
	更多表達(dá)數(shù)據(jù)
直系同源體
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A+醫(yī)學(xué)百科 >> 腺苷脫氨酶

Adenosine/AMP deaminase N-terminal

鑒定

標(biāo)志

A_deaminase_N

Pfam（蛋白家族查詢(xún)站）

PF08451

InterPro（蛋白數(shù)據(jù)整合站）

IPR013659

現(xiàn)有可用的蛋白結(jié)構(gòu)：
Pfam	structures
PDB（蛋白質(zhì)數(shù)據(jù)庫(kù)）	RCSB PDB; PDBe
PDBsum（蛋白質(zhì)三維結(jié)構(gòu)站）	structure summary

腺苷脫氨酶（英語(yǔ)：Adenosine deaminase）的是一種參與嘌呤代謝作用的酶。它是用作拆解食物組織中的核酸中的腺苷。

反應(yīng)

腺苷脫氨酶對(duì)腺苷進(jìn)行不可逆轉(zhuǎn)的脫氨作用,轉(zhuǎn)化腺苷為相關(guān)的核苷肌苷,移除氨基酸組。

病理學(xué)

腺苷脫氨酶的突變基因使之不容易被表達(dá),這是一些免疫缺陷病（ SCID ）的原因。基因突變令A(yù)DA被過(guò)度產(chǎn)生是溶血性貧血原因之一。有一些證據(jù)表明，一個(gè)不同的allelle (ADA2)可能會(huì)導(dǎo)致自閉癥。

參考文獻(xiàn)

深入閱讀

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