磷酸酯酶與張力蛋白同源物（英語：Phosphatase and tensin homolog，簡稱為PTEN）是一種在人體中由PTEN基因編碼的蛋白質(zhì)[2]。該基因的突變是多種癌癥進展過程的環(huán)節(jié)之一。
PTEN通過其磷酸酯酶蛋白產(chǎn)物而行使一種抑癌基因的作用。這一磷酸酯酶參與了細(xì)胞周期的調(diào)節(jié)，阻止細(xì)胞過快地生長與分裂[3]。其為癌微RNAMIRN21的靶之一。
該基因被鑒定為一種腫瘤抑制物，在多種癌癥中往往處于變異狀態(tài)。該基因編碼的蛋白質(zhì)是一種磷脂酰肌醇-3,4,5-三磷酸3-磷酸酯酶。該蛋白同時含有一張力蛋白樣結(jié)構(gòu)域及一催化結(jié)構(gòu)域，這與雙特異性蛋白酪氨酸磷酸酶很相似。但與大部分蛋白質(zhì)酪氨酸磷酸酶不同的是，該蛋白偏好脫去磷酸肌醇底物上的磷酸。該蛋白負(fù)性調(diào)控胞內(nèi)磷脂酰肌醇-3,4,5-三磷酸的水平，并通過負(fù)性調(diào)控Akt/PKB信號通道發(fā)揮抑癌基因的作用[4]。
參考文獻
- ↑ 1.0 1.1 PDB 1d5r；Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell. October 1999, 99 (3): 323–34. doi:10.1016/S0092-8674(00)81663-3. PMID 10555148.
- ↑ Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet.. April 1997, 15 (4): 356–62. doi:10.1038/ng0497-356. PMID 9090379.
- ↑ Chu EC, Tarnawski AS. PTEN regulatory functions in tumor suppression and cell biology. Med. Sci. Monit.. October 2004, 10 (10): RA235–41. PMID 15448614.
- ↑ Entrez Gene: PTEN phosphatase and tensin homolog (mutated in multiple advanced cancers 1).
深入閱讀
- Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997, 275 (5308): 1943–1947. doi:10.1126/science.275.5308.1943. PMID 9072974.
- Simpson L, Parsons R. PTEN: life as a tumor suppressor. Exp Cell Res. 2001, 264 (1): 29–41. doi:10.1006/excr.2000.5130. PMID 11237521.
- Chu EC, Tarnawski AS. PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit. 2004, 10 (10): RA235–41. PMID 15448614.
- Eng C. PTEN: one gene, many syndromes. Hum Mutat. 2003, 22 (3): 183–98. doi:10.1002/humu.10257. PMID 12938083.
- Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1199575/ The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis]. Genes Dev. 2005, 19 (17): 2054–65. doi:10.1101/gad.1308805. PMID 16107612. PMC 1199575.
- Leslie NR, Downes CP. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1133909/ PTEN function: how normal cells control it and tumour cells lose it]. Biochem J. 2004, 382 (Pt 1): 1–11. doi:10.1042/BJ20040825. PMID 15193142. PMC 1133909.
- Pilarski R, Eng C. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1735782/ Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome]. J Med Genet. 2004, 41 (5): 323–6. doi:10.1136/jmg.2004.018036. PMID 15121767. PMC 1735782.
- Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol. 2004, 22 (14): 2954–63. doi:10.1200/JCO.2004.02.141. PMID 15254063.
- Waite KA, Eng C. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC379112/ Protean PTEN: Form and Function]. Am J Hum Genet. 2002, 70 (4): 829–44. doi:10.1086/340026. PMID 11875759. PMC 379112.
- Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ, Bos C, Dasouki M, Feldman GL, Greenberg LA, Ivanovich J, Matloff E, Patterson A, Pierpont ME, Russo D, Nassif NT, Eng C. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1180378/ Germline PTEN Promoter Mutations and Deletions in Cowden/Bannayan-Riley-Ruvalcaba Syndrome Result in Aberrant PTEN Protein and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway]. Am J Hum Genet. 2003, 73 (2): 404–11. doi:10.1086/377109. PMID 12844284. PMC 1180378.
- Ji S-P, Zhang Y, Cleemput JV, Jiang W, Liao M, Li L, Wan Q, Backstrom JR, Zhang X. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Nature Medicine. 2006, 12 (3): 324–9. doi:10.1038/nm1349. PMID 16474401.
外部鏈接
PTEN (基因)引用了美國國家醫(yī)學(xué)圖書館提供的資料，這些資料屬于公共領(lǐng)域。
模板:蛋白酪氨酸磷酸酶類
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